Often yes: unlike the maestrale, which clears the sky, the grecale pushes humid air from the Tyrrhenian Sea against the eastern hills and can bring clouds and showers to the east coast. On the island's west side the sky usually stays clear — one more reason to pick the sheltered western beaches.
The grecale comes from the north-east: the best beaches are on the opposite side of the island or protected by headlands, where the wind comes off the land and the sea stays calm.
This page checks the live wind over Sardinia and highlights when the grecale is active. In forecasts, look at the wind direction: grecale = wind from the north-east.